long-term effects on brain cells ⋅ Inserm, From science to health


Regular consumption of caffeine permanently modifies the molecular functioning of the cells of the hippocampus, the seat of memory in the brain. This translates into greater neuronal plasticity, which may facilitate learning and improve memory.

Many people drink coffee. Some do it for taste, and many for the stimulating properties of caffeine. Indeed, the latter increases alertness and concentration in the hours following its consumption. It also has an effect on memory: several epidemiological studies and experimental studies attest to a benefit in the event of Alzheimer’s disease. A phase 3 study was even launched in 2021, in Lille, to assess the effect of caffeine on cognitive functions patients with an early or moderate form of this neurodegenerative disease (CAFCA study